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ResearchMonitoringtES + EEG + fNIRS

tES + EEG + fNIRS

Simultaneous tri-modal experimentation combining brain oscillations, hemodynamic activity, and neuromodulation. One single headcap. Fully mobile.

Tri-modal stimulation head cap with model

There is growing interest in true tri-modal experiments combining tES,EEG, and fNIRS. Rather than assessing whether neuromodulation alters neuronal oscillations or hemodynamic responses in isolation, this integrated approach enables investigation of the coupling between neural and vascular dynamics. While neural activity evaluated by EEG indexes the synchronous activation of a large population of pyramidal neurons, fNIRS monitors downstream hemodynamic responses, exploiting neurovascular coupling to infer regional synaptic activity from localized shifts in cerebral blood flow. Therefore, by integrating electrophysiological and hemodynamic measures, tri-modal paradigms provide a mechanistic framework for uncovering how tES influences brain function across different levels, from neuronal activity, to hemodynamics to systemic.

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A Fully Integrated Tri-Modal Solution

Soterix Medical combines the M×N-GO EEG platform with the Artinis Brite MKIV to enable simultaneous HD-tES, EEG, and fNIRS in a single wearable setup. The M×N-GO EEG provides up to 33 channels of HD-tES stimulation and 32 channels of research-grade wireless EEG. The Brite MKIV adds up to 27 fNIRS channels per system, with scalable MultiBrite configurations including TetraBrite, which combines four Brite systems to provide 100+ channels for near full-head coverage.

The integrated headcap supports flexible multimodal placement. HD-tES stimulation and EEG electrodes can be housed within the same holder, while hybrid configurations can also accommodate fNIRS optodes and HD-tES electrodes together at the same location. All three modalities are not co-located within a single holder.

Full Tri-modal Integration

Seamless Synchronization Across Modalities

The M×N-GO EEG combines stimulation and EEG within a single platform, allowing stimulation events to be captured directly as markers within the EEG recording. The EEG data stream is LSL-compatible, while the Brite MKIV supports LSL through Brite Connect, enabling synchronized EEG and fNIRS acquisition and shared experimental event timing.

Wired stimulation triggers are recorded directly as event markers within the M×N-GO EEG data. With the EEG and Brite MKIV streams synchronized through LSL, these stimulation events can then be temporally aligned with both electrophysiological and hemodynamic recordings.

Together, the platform enables simultaneous investigation of electrophysiological activity, cortical hemodynamics, and targeted neuromodulation in a compact, mobile tri-modal research environment.

Multi modal Compability

Validated Multimodal Compatibility

The tri-modal configuration builds on an established approach for combining fNIRS and EEG using independent sensor holders. In prior validation testing using the same Brite fNIRS platform, independent fNIRS optodes and EEG electrodes were positioned as close as 30 mm apart with no measurable interference observed in the EEG signal. Expected physiological activity, including the alpha rhythm, remained clearly detectable while the fNIRS system was active.

The M×N-GO EEG + Brite MKIV configuration applies this same independent-holder architecture, allowing EEG electrodes and fNIRS optodes to be positioned flexibly across the scalp while maintaining physical separation between the two sensing modalities. This approach supports simultaneous electrophysiological and hemodynamic recording without requiring co-located EEG/fNIRS holders.

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Caution! Investigational Device. Federal (or United States) law limits device to investigational use.