Targeting is performed in three easy steps
Choose the number of current sources – 4, 8, 16 or 32 electrodes.
Pick the field orientation (Radial, Tangential, and more) and Optimization Criteria (max focality or max intensity).
Choose your desired brain target either as a region (1100 Talairach locations, labels from the Human Connectome Project, voxel) or guided by EEG.
HD-Targets™ is protected by patents, other intellectual property rights, patents pending or other intellectual property rights pending.
Since conventional IF/TI stimulation involves 2 current sources, targeting is performed in two easy steps:
Compatible with Soterix Medical HD-IFS device. The HD-Targets-IFS extension is included as part of the HD-Targets software.
One can leverage the reciprocity principle to target the source of recorded EEG. The image on the left below indicates neural activation and resulting EEG map. Using reciprocity algorithm, a corresponding optimal electrode placement to target the brain activation source can be determined. The image of the right indicates the implementation of this feature in HD-Targets. Simply load a vector of voltage values corresponding to the EEG locations. Select the number of current sources in your stimulator. Obtain Optimized Montage.
It is known that multiple brain regions and networks are involved in the pathogenesis of certain conditions, making it rational to optimize montages that allow simultaneous targeting of these regions. In fact, it has been shown that targeting as many as 5 brain regions, require ~30 electrodes (Huang 2018). Even when targeting just 2 brain regions, fully independent waveform (e.g. frequency) control optimizes neuromodulation (Reinhart and Nguyen 2019). Now use HD-Targets (v 4.0) to perform simultaneous multi-region targeting.
Define any plane in the 3D space by selecting appropriate angle and location via distance from center. Cut 3D volume at the plane to visualize depth activation.
Define any line in the 3D space by selecting start point and end point. Export electric field values induced along the line to a text file for further post-processing such as to perform statistical analysis.
Define any sphere in the 3D space by selecting a center point and then defining the radius of the sphere. Export electric field values induced within the sphere to a text file for further post-processing such as to perform statistical analysis.
